A major review published in The Lancet finds most statin side-effects are not caused by the drugs.
Researchers analysed 19 trials involving 124,000 people followed for more than four years.
Evidence supported only muscle pain, diabetes risk, and four minor side-effects.
These included small liver test changes, urine changes, and tissue swelling.
The study found no link between statins and memory loss, depression, or sleep problems.
Lead author Christina Reith said benefits clearly outweigh risks for most patients.
Experts called for updated drug labels to reflect the evidence and counter misinformation.
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